The objective of the present study was to design and formulate TDDS of topiramate (TPM) and to evaluate their extended release in vitro and ex. used were of analytical grade. Preparation of TDDS. Composition of formulation of transdermal patches was showed in Table 1. The polymeric solution (10%. The purpose of this research work was to Formulation and evaluation of transdermal drug systems (TDDS) which can deliver medicines via the skin portal to.

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The cumulative percent of drug release in 12 h was noted.

Formulation and evaluation of transdermal drug-delivery system of isosorbide dinitrate

Then, the drug was added slowly in the polymeric solution and stirred with the help of magnetic stirrer to obtain a uniform solution. Comparative drug permeation profiles of transdermal drug delivery system rdds oleic acid. Comparative drug release profiles of transdermal drug delivery system with carbopol. The saturated solution was filtered and then measured by HPLC.

Drug Dev Ind Pharm. Comparison release of the developed patch with formulatio controlling group. Oleic acid and tween 80 were used as the penetration enhancer.

Compatibility study of drug with the excipients was determined by Fourier transform infrared FTIR spectroscopy Shimadzu The structure of acrylate monomers.

When PVA was used as the drug reservoir, urea was used as the penetration enhancer and M1 was used as the rate-controlling membrane, the in vitro release behaviour firmulation the PSA through the rats’ ex-vivo skin was studied.

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Study on percutaneous therapeutic system of isosorbide dinitrate effect of penetration enhancers on in vitro permeability evalutaion rat skin. In microscopic pictures of formulations prepared from CAP, surface morphology was good in lower concentrations.


Development of a reservoir-type transdermal delivery system containing eucalyptus oil for tetramethylpyrazine. This result could be explained by the pore sizes of membrane M1, which was fabricated randomly by polymer chains. But, such film-like acrylate polymers have not been applied in the production of patches to date.

Formulation and Evaluation of Transdermal Patch of Repaglinide

The moisture content in the patches ranged from 3. The prepared formulations with different polymer concentrations were smooth, opaque, flexible and uniform. So ans coefficient gives no significance effect.

Effect of the rate-controlling membrane on the permeation To screen a suitable rate-controlling membrane, different concentrations of ISDN in 1,2-propylene glycol solution 1.

Transdermal patch of Repaglinide was prepared to sustain the release and improve bioavailability of drug and patient compliance. The in vitro release data showed that drug release from the patch has been affected by the type and concentration of the polymer.

From this, we can infer that concentration of the HPMC polymer plays a key role in drug release kinetics with a permeation enhancer.

The average and standard deviation of five readings were calculated for three batches of the optimised formulation with an area of 1 cm 2. Specificity A set of sample solutions were prepared to ascertain the specificity of the method. The developed patch was fabricated by a temporary liner, an adhesive layer, a rate-controlling membrane, a reservoir and a backing.

View at Google Scholar S. Thus, we could surmise the permeation rates of the drug transporting through the human skin would be less than the values of rat skin. Comparing in vitro releasing behavior of formulation group F7 and Frandol r Tape, it was found that both groups could control drug release at a sustained rate for up to 48 h.


The mixed solution was casted onto a glass plate with cm 2 areas, and then the plate was put in an oven Hanzhou Huier Equipment Co. Dosage frequency of Repaglinide is 0. Ind J Pharm Sci. Formulation of transdermal patch In the present study, drug loaded matrix type transdermal patches of TPM were prepared by solvent casting method[ 21 ] using different ratios of hydroxyl propyl methyl cellulose HPMCethyl cellulose, polyvinylpyrrolidone PVPeudragit L, Cellulose acetate phthalate CAPcarbopol and polyvinyl alcohol PVA.

The number of times the film was folded at the same place without breaking gave the value of the folding endurance. Comparison of human skin or epidermis models with human and animal skin in in-vitro percutaneous absorption. Thus, it was easy to tune release rate and release time to achieve the prediction.

Among the ISDN transdermal patches designed and reported previously, the drug-in-adhesive patches are the simplest and the most commonly used design. The release profile of all batches were fitted to various mathematical models such as Zero order, First order, Higuchi [ 11 ], Hixon and Crowell [ 12 ], and Korsmeyer et al. The drug release characteristics of the formulation were studied in in vitro conditions by using artificial semipermeable membrane.