Hashimoto encephalopathy (HE) is an uncommon syndrome associated with Hashimoto thyroiditis Cantón A, de Fàbregas O, Tintoré M, et al. Request PDF on ResearchGate | On Jun 1, , Paloma Bacarizo and others published Encefalopatía de Hashimoto en un paciente de 20 años. CLINICAL/SCIENTIFIC NOTE. Hashimoto’s encephalopathy. Encefalite de Hashimoto. Renata Telles Rudge de AquinoI; Eduardo Genaro MutarelliII.

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Up to there were almost published case reports of this disease. Degenerative SA Friedreich’s ataxia Ataxia-telangiectasia.

Hashimoto’s encephalopathy

J Clin Endocrinol Metab ; The symptoms were recurrent and reversible and were not associated with thyroid dysfunction 1. It is sometimes referred to as a neuroendocrine disorder, although the condition’s relationship to the endocrine system is widely disputed.

Like other autoimmune disease improvement may occur spontaneously 4. Its two sub-types can co-exist: Further controlled studies of the use of steroids, plasmapheresis, or immunosuppressant medications are needed in the future to prove the concept of the pathogenic role of antithyroid antibodies in HE.

It is probably under diagnosed as it is not well known 5. Services on Demand Journal.

The patients met the clinical criteria for Creutzfeldt-Jakob disease and were notified 8. Department of Medical Genetics.


The clinical manifestations can be fluctuating or persistent, and reversible, if properly treated with immunosuppressive therapy 3. Hashimoto’s encephalopathy is a rare condition associated with Hashimoto thyroiditis, the presence of high concentrations of anti-thyroid antibodies, without any evidence of thyroid dysfunction, and an excellent response to treatment with corticosteroids 2.

Normotensive, pulse bpm, she had universal alopecia, cyanosis and pale alternating in the extremities, growing nails of the right hand and encefaopatia on her back and face.

Encefalopatia de Hashimoto | SPEDM Journal

The mechanism of pathogenesis is not known but it has been hypothesized to be an autoimmune disorder, similar to Hashimoto’s thyroiditis as its name encecalopatia. Services on Demand Journal. Long-term treatment of Hashimoto’s encephalopathy. The first case of HE was described by Brain et al.

The thyroid-stimulating hormone TSH was slightly elevated at 7. Isolated angiitis of the CNS associated with Hashimoto’s disease.

Hashimoto’s encephalopathy with clinical features similar to those of Creutzfeldt-Jakob disease

Japan, and Depannient of Anatomy and Biology. Consistent with this hypothesis, autoantibodies to alpha-enolase have been found to be associated with Hashimoto’s encephalopathy. Migraine Familial hemiplegic Cluster Tension.

In an epidemiological study made by Seipelt et al.

Encefalopatia de Hashimoto

Poliomyelitis Demyelinating disease Transverse myelitis Tropical spastic paraparesis Epidural abscess. Accepted 23 September The recognition of the condition was essential for the treatment and ds of the clinical presentation.


Ataxia, low amplitude high frequency action and postural tremors and myoclonus were observed in the four limbs.

Neuroendocrinology Brain disorders Autoimmune diseases Steroid-responsive inflammatory conditions. She had a 6 month haahimoto of behavioral changes and agitation, resulting in psychiatric treatment of estazolan 2 mg, bupropion mg, carbamazepine mg and duoxetine 30 mg daily. Antithyroid antibodies in the CSF: We believe encefzlopatia this pathology is misdiagnosed, therefore, tests detecting the presence of anti-thyroid antibodies are recommended in a clinical presentation of encephalopathy of subacute onset or rapidly progressive dementia associated with myoclonus and triphasic complexes in the EEG, when the ethiology is not identified.

Creutzfeldt-Jakob disease hashomoto a progressive and inexorably fatal course, as opposed to Hashimoto’s encephalopathy, which has a fluctuating course and excellent response to treatment with corticosteroids.

A female patient, years-old, Caucasian, widow, born in Rio de Janeiro, developed a clinical presentation of daily sadness, discouragement, decreased appetite, insomnia, and cognitive decline.