Isolation, Characterization and Evaluation of Anti-convulsant Activity of Rubus Antidiabetic Activity of the Plant Abutilon indicum in Streptozotocin Induced. Abutilon hirtum extract and fractions exhibited anti-inflammatory analgesic, antipyretic and antipyretic activities which may be attributed by the. Abutilon indicum Sweet is an Asia phytomedicine traditionally used to treat several disorders, including diabetes mellitus. However, molecular.

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Specific oligonucleotide primers were designed using the Primer3 program http: However, traditional antidiabetic plants possess less adequate scientific or medicinal data support in spite of the fact that the World Health Organization still recommends further evaluation of their accepted use [ 89 ]. The species suggests phytomedicine for anti-inflammatory, antimicrobial, antibacterial activities with industrial applications which are based on the antioxidant potential of the species.

Tress is extensively tapped for their resin in India and is the main source of resin in that region. As demonstrated in this study, extract of A. The combinations of these characters provide reliable characters for species identification. Indexed in Science Citation Index Expanded.

Since troglitazone TGZ was voluntarily withdrawn from the market in March due to occurrence of severe idiosyncratic liver injury, it is necessary to establish a safer compound that shows antidiabetic activity. This pathway has been reported to be involved in the regulation of GLUT 1 expression [ 47 ].

In the follow-up studies, we examined potential mechanisms underlying the improvement in glucose utilization by the extract. The medicinal plants are widely used by the traditional medical practitioners for curing various diseases in their day to day practice.

Subsequently, we found that crude extract of A. Antidiabetic Activity of A. In this report, we examined whether the extract of A. As shown in Figure 5the extract enhanced glucose uptake in a concentration-dependent manner. The results revealed that the leaves contain steroids, sapogenins, carbohydrates and flavonoids. Previous literature has documented that the phosphatidylinositolkinase PI3K pathway plays an important role in the insulin signaling cascade leading to glucose transport translocation [ 44 ].


Thus, these data imply that the butanol fraction of A. The animals were weighed on day 0, 4, 7, 11 and 14 for corrected doses of medication. The alkaloid berberine has also been reported to activate GLUT1-mediated glucose uptake [ 48 ]. View at Google Scholar N. The turpine obtained from resin of tree is antiseptic, diaphoretic, diuretic, rubefacient, stimulant and vermifuge.

Thus, extrapancreatic action such as stimulating liver and muscle fructose-2,6-bisphosphate formation may be involved in the effect of both glibenclamide and extracts used in this study rather than insulin secretion.

For pharmaceutical purposes, the quality of medicinal plant material must be high as that of other medicinal preparations. Antidibetic, Amarin, Bangkok, Thailand, Looking for Past Issues? The filtrate was lyophilized in a freeze dry system resulting in a dark brown powder anntidiabetic The pGL3-Basic vector empty was used as a negative control, and pGL3-control vector was used for a positive control.

Diabetes or obesity causes substantial morbidity, mortality and long-term complications, and remains an important risk factor for cardiovascular disease [ 1 ]. Another pathway that has been implicated in glucose transport, not by translocation of GLUT, but by activation of GLUT, is the p38 pathway [ 46 ], which is also interesting for further study.

It is used internally as well as externally for many diseases. The present study antidiabwtic the quality control study of parameters of leaves of Tylophora indica Brum.

Volume2,Issue2 – Pharmacognosy Phytochemistry

We found that A. The results revealed that the use of leaves in controlling diabetes mellitus is justifiable. Binding Activity of A. Extracts of the roxburgii were tested for growth inhibitory against bacterial plant pathogens, mosquito. The leaves of Abutilon indicum Linn. As there is no detailed on the standardisation work reported on stem, the physicochemical parameters, brief study on pharmacological activities and microbial contamination analysis are carried out.

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Dhirender Kaushik, Ajay Kumar, A. View at Google Scholar E. The needles being rich in resin content is a highly inflammable fuel for igniting forest fires. The defective glucose transport system may play an important role in the pathogenesis of peripheral insulin resistance, and glucose uptake in target tissues is a critical step in maintaining glucose homeostasis and in clearing the postprandial glucose load [ 45 ]. This plant has a long history of being used medicinally as an antidiabetic remedy, and phytochemical screening of the plant revealed that it contained alkaloids, flavonoids, tannins, saponins and glycosides [ 1011 ].

This result will require confirmation such as measuring extracellular signal regulated kinases ERKswhich have been known to be responsible for the expression of GLUT1 [ 48 ]. A number of medicinal uses has been reported some important acyivity are Antioxidant, antihelmintic activity, Hepato-Protective activity, antidiarrhoeal activity, Tumor growth inhibitory activity.

The effect of crude antidiabeyic of A. The plant of Abutilon indicum is available in reach source at Melghat tiger reserve forest area.

Evidence-Based Complementary and Alternative Medicine

Oleanolic acid has been reported antidiabeic have hypoglycemic activity by acting as an inhibitor of glycogen phosphorylase, leading to the inhibition of hepatic glycogenolysis [ 50 ]. Another important finding of this work is that the extract of A. Evidence-Based Complementary and Alternative Medicine. Journal Issues Vol 20, Dec. Subsequently, we examined the effect of the extract on transcription activation of GLUT1.